This could be something that only affects me and not people with different keyboard layouts, so let me know if it isn't the case.
Despite having logged about two thousand hours in game, I find myself imputing wrong commands from time to time.
Two of these are very bothersome. Waiting instead of zooming out and Sleeping instead of Switching weapons.
In the first case, pressing "-" without holding "CTRL" results in the player character losing animals that are being tracked.
Most recently, I tried switching weapons on a road only to have the character fall asleep instead, waking up to "You hear silent voices from the shadows, and notice your limbs are aching a lot". (Which might come across as a reference to rape to some people.)
This last interaction might very well mean death on a fight. I believe it could be solved by adding a warning before the action is carried forward, similar to trying to walk into water or on thin ice.