Just throwing my hat in the ring of suggestions for mods or things this creative community may be able to come up with. No personal skill, not responsible.
Health - please ruin my early to mid game with.....
Tooth decay? Abscesses?
Myopia/glaucoma
Epilepsy - could be brought on by trauma as IRL
PTSD from murder/unsavoury acts - Low days/flashbacks
Disturbed sleep from trauma/guilt - impact on piety/choices in dreams?
Elephant in the room, is cannibalism coming back as an rpg choice?